Bethyl Laboratories
Rabbit anti-FANCD2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00624
TargetFANCD2
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
FANCD2 (Fanconi anemia, complementation group D) is a protein involved in DNA repair. Defects in FANCD2 are the cause of Fanconi anemia, a heterogenous autosomal recessive disorder characterized by congenital malformations and a predisposition to cancer. The FANCD2 gene is one of 13 complementation groups that include FANCA, FANCB, FANCC, FANCD1/BRCA2, FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ/BRIP1, FANCL, FANCM, and FANCN/PALB2. The FANC members are not homologous proteins but are related by their assembly into a common nuclear complex.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1401 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetFANCD2
Antigen Species
Human
Gene ID2177
Gene Symbol
FANCD2
Gene Name
FA complementation group D2
Uniprot IDQ9BXW9
Protein Name
Fanconi anemia group D2 protein
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to FANCD2 immobilized on solid support.
The epitope recognized by IHC-00624 maps to a region between residue 1401 and 1451 of human Fanconi anemia, complementation group D2 using the numbering given in entry NP_001018125.1 (GeneID 2177).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00624Open
Product DatasheetPDF · IHC-00624 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00624 · Lot 1 (current lot)Open
Citations / Publications
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Resources
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