Bethyl Laboratories
Rabbit anti-FKBP4/FKBP52 Antibody Affinity Purified
Primary
Catalog #A301-428A
TargetFKBP4/FKBP52
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationWB
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Product Description
FKBP4/FKBP52 is an immunophilin and target of FK506, a macrolide immunosuppressive drug derived from Streptomyces tsukubaensis. Like other FK506 binding proteins, FKBP52 exhibits peptidyl-prolyl cis-trans isomerase activity, but does not appear to mediate the immunosuppressive activities of FK506. The most studied role of FKBP4/FKBP52 surrounds its involvement in the regulation of steroid receptor signaling. In association with the molecular chaperone Hsp90, FKBP4/FKBP52 is able to influence steroid-hormone binding affinity and transcriptional activity.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 409 and C-terminus
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
200 µg/ml
Target Identity
TargetFKBP4/FKBP52
Antigen Species
Human
Gene ID2288
Gene Symbol
FKBP4
Gene Name
FK506 binding protein 4
Uniprot IDQ02790
Protein Name
Peptidyl-prolyl cis-trans isomerase FKBP4
Alternate Names
51 kDa FK506-binding protein • 52 kDa FK506-binding protein • 52 kDa FKBP • 59 kDa immunophilin • FK506 binding protein 4, 59kDa • FK506-binding protein 4 • FKBP-4 • FKBP51 • FKBP52 • FKBP-52 • FKBP59 • HBI • HSP binding immunophilin • Hsp56 • HSP-binding immunophilin • Immunophilin FKBP52 • p52 • p59 • peptidylprolyl cis-trans isomerase • peptidyl-prolyl cis-trans isomerase FKBP4 • PPIase • PPIase FKBP4 • rotamase • T-cell FK506-binding protein, 59kD
Product Information
Applications
WB
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to FKBP4/FKBP52 immobilized on solid support.
The epitope recognized by A301-428A maps to a region between residue 440 and 459 human FK506 binding protein 4 using the numbering given in entry NP_002005.1 (GeneID 2288).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (A120-101P).
Western Blot (WB)1:2000 - 1:10,000
Documents
Product DatasheetPDF · A301-428A · Lot 1 (current lot)Open
Product DatasheetPDF · A301-428A · Lot 1 (current lot)Open
Safety Data SheetPDF · A301-428AOpen
Citations / Publications
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