Bethyl Laboratories
Rabbit anti-FOXO3a IHC Antibody Affinity Purified
Primary
Catalog #IHC-00434
TargetFOXO3a
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
Image 1 of 2
local_shipping
Order within 21 hours and 36 minutes for shipment by today
Product Description
Forkhead box protein 03A (FOXO3a) belongs to a large family of Forkhead proteins that possesses a winged-helix DNA-binding domain called Forkhead box (FOX). FOXO3a is a transcription factor that functions to induce apoptosis in the absence of survival factors and in response to oxidative stress. Under conditions of oxidative stress FOXO3a is acetylated and localized to the nucleus where it may act as a transcriptional repressor.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 623 and C-terminus
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetFOXO3a
Antigen Species
Human
Gene ID2309
Gene Symbol
FOXO3
Gene Name
forkhead box O3
Uniprot IDO43524
Protein Name
Forkhead box protein O3
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to FOXO3a immobilized on solid support.
The epitope recognized by IHC-00434 maps to a region between residue 625 and the C-terminus (residue 673) of human Forkhead Box O3a using the numbering given in Swiss-Prot entry O43524 (GeneID 2309).
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00434Open
Product DatasheetPDF · IHC-00434 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00434 · Lot 1 (current lot)Open
Citations / Publications
Services
Antibody Conjugation
Antibody and conjugate formats developed together, built to your specification.
Request CustomizationCustom Monoclonal Antibody Discovery Services
Full custom monoclonal development, from immunization through validation.
Explore Monoclonal DevelopmentVHH Discovery
Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
Explore VHH DiscoveryResources
1