Bethyl Laboratories
Rabbit anti-Gigaxonin Antibody Affinity Purified
Primary
Catalog #A302-907A
TargetGigaxonin
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
Gigaxonin is a probable cytoskeletal component that directly or indirectly plays an important role in neurofilament architecture. It is also a substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins such as TBCB, MAP1B, and MAP1S and is critical for neuronal maintenance and survival [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9H2C0].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 150 and 200
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetGigaxonin
Antigen Species
Human
Gene ID8139
Gene Symbol
GAN
Gene Name
gigaxonin
Uniprot IDQ9H2C0
Protein Name
Gigaxonin
Alternate Names
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to Gigaxonin immobilized on solid support.
The epitope recognized by A302-907A maps to a region between residue 150 and 200 of human Gigaxonin using the numbering given in entry NP_071324.1 (GeneID 8139).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A302-907A · Lot 1 (current lot)Open
Product DatasheetPDF · A302-907A · Lot 1 (current lot)Open
Safety Data SheetPDF · A302-907AOpen
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