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Rabbit anti-HEXIM1 Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
HEXIM1
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 1 and 50
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

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Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to HEXIM1 immobilized on solid support.

The epitope recognized by A303-111A-T maps to a region between residue 1 and 50 of human Hexamethylene Bis-Acetamide Inducible 1 using the numbering given in entry NP_006451.1 (GeneID 10614).

Immunoglobulin concentration was determined by extinction coefficient: absorbance at 280 nm of 1.4 equals 1.0 mg of IgG.

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Gene & Protein Information

Hexamethylene bis-acetamide-inducible protein 1 (HEXIM1) is a transcriptional regulator which functions as a general RNA polymerase II transcription inhibitor. In cooperation with 7SK snRNA, HEXIM1sequesters P-TEFb in a large inactive 7SK snRNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. HEXIM1 may also regulate NF-kappa-B, ESR1, NR3C1 and CIITA-dependent transcriptional activity [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O94992].

10614

HEXIM1

hexamethylene bisacetamide inducible 1

O94992

Protein HEXIM1

Alternate Names

cardiac lineage protein 1, CLP1, EDG1, estrogen down-regulated gene 1 protein, hexamethylene bis-acetamide inducible 1, hexamethylene bisacetamide-inducible protein, hexamethylene bis-acetamide-inducible protein 1, hexamethylene-bis-acetamide-inducible transcript 1, hexamthylene bis-acetamide inducible 1, HIS1, HMBA-inducible, MAQ1, menage a quatre 1, menage a quatre protein 1, protein HEXIM1

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-12% SDS-PAGE.

Citations (1)