Bethyl Laboratories
Rabbit anti-INPPL1/SHIP2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00567
TargetINPPL1/SHIP2
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
INPPL1 (Inositol Polyphosphate Phosphatase-Like Protein 1) is a phosphatidylinositol phosphatase that negatively regulates phosphoinositide 3-kinase (PI3K) pathways related to numerous cell activities. INPPL1 plays a role in PI3K-dependent insulin, macrophage colony-stimulating factor, and EGF signaling. INPPL1 is also involved in actin cytoskeletal remodeling, actin dynamics, and neuritogenesis. INPPL1 interacts with SHC1 (src-homology domain) to mediate EGFR signaling.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 100 and 150
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetINPPL1/SHIP2
Antigen Species
Human
Gene ID3636
Gene Symbol
INPPL1
Gene Name
inositol polyphosphate phosphatase like 1
Uniprot IDO15357
Protein Name
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2
Alternate Names
51C protein • Inositol polyphosphate phosphatase-like protein 1 • INPPL-1 • OPSMD • phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2 • protein 51C • SH2 domain-containing inositol 5'-phosphatase 2 • SH2 domain-containing inositol phosphatase 2 • SH2 domain-containing inositol-5'-phosphatase 2 • SHIP2 • SHIP-2
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to INPPL1/SHIP2 immobilized on solid support.
The epitope recognized by IHC-00567 maps to a region between residues 100 and 150 of human inositol polyphosphate phosphatase-like 1 using the numbering given in entry NP_001558.2 (GeneID 3636).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00567Open
Product DatasheetPDF · IHC-00567 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00567 · Lot 1 (current lot)Open
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