Bethyl Laboratories
Rabbit anti-IRS2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00356
TargetIRS2
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC, IHC-IF
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Product Description
IRS2 (insulin receptor substrate 2) functions as a cytoplasmic link and transducer of insulin receptor (IR) and insulin-like growth factor receptor (IGFR) signaling. As the name implies, IRS2 is a substrate of IR and IGFR tyrosine kinase activity activated by insulin and IGF binding.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1288 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetIRS2
Antigen Species
Human
Gene ID8660
Gene Symbol
IRS2
Gene Name
insulin receptor substrate 2
Uniprot IDQ9Y4H2
Protein Name
Insulin receptor substrate 2
Alternate Names
Product Information
Applications
IHC, IHC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to IRS2 immobilized on solid support.
The epitope recognized by IHC-00356 maps to a region between residue 1288 and 1338 of human insulin receptor substrate 2 using the numbering given in entry NP_003740.2 (GeneID 8660).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Immunohistochemistry-Immunofluoresence (IHC-IF)1:50 - 1:500
Documents
Safety Data SheetPDF · IHC-00356Open
Product DatasheetPDF · IHC-00356 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00356 · Lot 1 (current lot)Open
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