Rabbit anti-Kaiso Antibody
Catalog #
Kaiso
Human
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 375 and 425
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Transcriptional regulator Kaiso possesses bimodal DNA-binding specificity and binds to methylated CGCG and also to the non-methylated consensus KAISO-binding site TCCTGCNA. Kaiso contains an N-terminal POZ/BTB domain and 3 C-terminal zinc finger motifs. It recruits the N-CoR repressor complex to promote histone deacetylation and the formation of repressive chromatin structures in target gene promoters. Kaiso may contribute to the repression of target genes of the Wnt signaling pathway, and may also activate transcription of a subset of target genes by the recruitment of catenin delta-2 (CTNND2). Its interaction with catenin delta-1 (CTNND1) inhibits binding to both methylated and non-methylated DNA. [taken from NCBI Entrez Gene (Gene ID: 10009)].
Alternate Names
kaiso transcription factor; transcriptional regulator Kaiso; WUGSC:H_DJ525N14.1; zinc finger and BTB domain-containing protein 33; ZNF348; ZNF-kaiso
Applications