Bethyl Laboratories
Rabbit anti-KAP-1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00072
TargetKAP-1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationICC-IF, IHC
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Product Description
KAP-1 (KRAB-Associated Protein 1) is a member of the tripartite motif RBCC/Trim domain family that contains a RING finger domain, B boxes, and an alpha helical coiled coil region. KAP-1 functions as a corepressor by interacting with the KRAB domain of KRAB zinc-finger transcriptional repressors. KAP-1 also appears to function as a scaffold for chromatin-remodeling complexes involved in transcriptional repression.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1 and 50
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetKAP-1
Antigen Species
Human
Gene ID10155
Gene Symbol
TRIM28
Gene Name
tripartite motif containing 28
Uniprot IDQ13263
Protein Name
Transcription intermediary factor 1-beta
Alternate Names
E3 SUMO-protein ligase TRIM28 • KAP1 • KAP-1 • KRAB Kruppel-associated box domain-associated protein 1 • KRAB-associated protein 1 • KRAB-interacting protein 1 • KRIP-1 • nuclear corepressor KAP-1 • PPP1R157 • protein phosphatase 1, regulatory subunit 157 • RING finger protein 96 • RING-type E3 ubiquitin transferase TIF1-beta • RNF96 • TF1B • TIF1B • TIF1-beta • transcription intermediary factor 1-beta • transcriptional intermediary factor 1-beta • Tripartite motif-containing protein 28
Product Information
Applications
ICC-IF, IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to KAP-1 immobilized on solid support.
The epitope recognized by IHC-00072 maps to a region between residue 1 and 50 of human Tripartite Motif-Containing 28 using the numbering given in entry NP_005753.1 (GeneID 10155).
Applications
Formalin-fixed, paraffin-embedded tissue 1:100 - 1:500:
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Formaldehyde-fixed cells 1:100 - 1:500.
Immunocytochemistry-Immunofluoresence (ICC-IF)1:100 - 1:500
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00072Open
Product DatasheetPDF · IHC-00072 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00072 · Lot 1 (current lot)Open
Services
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