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Rabbit anti-Ku70 Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
Ku70
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 500 and 550
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (200 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

For ordering information, see our International Distributors

Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
40 µg/ml
200 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to Ku70 immobilized on solid support.

The epitope recognized by A302-624A-T maps to a region between residue 500 and 550 of human Lupus Ku autoantigen protein p70 using the numbering given in entry NP_001460.1 (GeneID 2547).

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Gene & Protein Information

Ku70 is the 70 kDa subunit of the lupus Ku autoantigen. The lupus Ku autoantigen was identified in individuals with systemic lupus erythematosus (SLE) and related disorders. The Ku antigen is a heterodimer of Ku70 and Ku80. The Ku70/Ku80 complex functions as a single-stranded DNA-dependent ATP-dependent helicase. The complex may be involved in the repair of nonhomologous DNA ends such as that required for double-strand break repair, transposition, and V(D)J recombination. [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P12956].

2547

XRCC6

X-ray repair cross complementing 6

P12956

X-ray repair cross-complementing protein 6

Alternate Names

5'-deoxyribose-5-phosphate lyase Ku70, 5'-dRP lyase Ku70, 70 kDa subunit of Ku antigen, ATP-dependent DNA helicase 2 subunit 1, ATP-dependent DNA helicase II 70 kDa subunit, ATP-dependent DNA helicase II, 70 kDa subunit, CTC box binding factor 75 kDa subunit, CTC75, CTCBF, DNA repair protein XRCC6, G22P1, Ku autoantigen p70 subunit, Ku autoantigen, 70kDa, KU70, lupus Ku autoantigen protein p70, ML8, thyroid autoantigen 70kDa (Ku antigen), thyroid-lupus autoantigen p70, TLAA, X-ray repair complementing defective repair in Chinese hamster cells 6, X-ray repair cross-complementing protein 6

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-8% SDS-PAGE. Western blot of lysates performed using standard western blot reagents and 4-8% SDS-PAGE.

Citations (1)