/ ANTIBODIES/ANTISERA / Primary Antibodies / Rabbit anti-MCAK IHC Antibody
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Primary Antibodies  

Bethyl Laboratories® Rabbit anti-MCAK IHC Antibody, Affinity Purified - 100 µl (50+ slides)

bethyl
Bethyl Laboratories

Catalog #

Validated
Target:

MCAK

Reactivity:

Human

Applications:

IHC

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

Between 50 and 100

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (50+ slides)

10 µl (5+ slides)

Product Details

Specifications
Verified Reactivity

Human

Presumed Reactivity

Horse,

Rabbit,

Monkey

Antigen Species

Human

Concentration
250 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide


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Additional Product Information

Kinesin activity has been linked to various cellular functions such as vesicle transport, mitotic spindle formation, chromosome segregation, chromosome congression, and cytokinesis. Structurally, all kinesins contain a motor domain with microtubule and nucleotide binding sites that utilize ATP to target cargo along microtubule filaments. MCAK (Mitotic Centromere-Associated Kinesin) is the founding member of kinesin-13 proteins. There are 3 independent genes coding for kinesin-13 proteins kif2a, kif2b, and kif2c (MCAK). Instead of functioning as a translocator of microtubules MCAK is a depolymerizer that is primarily responsible for releasing improper microtubule-kinetochore attachments during cell division.

11004

KIF2C

kinesin family member 2C

Q99661

Kinesin-like protein KIF2C

Alternate Names

CT139; kinesin-like protein 6; kinesin-like protein KIF2C; KNSL6; MCAK; mitotic centromere-associated kinesin; testis tissue sperm-binding protein Li 68n

Applications

Epitope exposure is recommended.

Epitope exposure with citrate or tris-EDTA pH9.0 buffer will enhance staining.

Likely to work with frozen sections.

In some cases, the antibody may be diluted further than indicated.