Bethyl Laboratories
Rabbit anti-MCM6 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00047
TargetMCM6
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
The MCM (Mini-Chromosome Maintenance) complex is a key component of the pre-replication complex involved in replication licensing which restricts DNA replication to only once per cell cycle. The MCM complex is a heterohexamer of MCM2, MCM3, MCM4, MCM5, MCM6, and MCM7. MCM6 is part of the core MCM complex that includes MCM4, MCM6, and MCM7. The core complex possesses DNA helicase activity.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 771 and C-terminus
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetMCM6
Antigen Species
Human
Gene ID4175
Gene Symbol
MCM6
Gene Name
minichromosome maintenance complex component 6
Uniprot IDQ14566
Protein Name
DNA replication licensing factor MCM6
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to MCM6 immobilized on solid support.
The epitope recognized by IHC-00047 maps to a region between residue 775 and the C-terminus (residue 821) of human Minichromosome Maintenance 6 using the numbering given in entry NP_005906.2 (GeneID 4175).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00047Open
Product DatasheetPDF · IHC-00047 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00047 · Lot 1 (current lot)Open
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