Bethyl Laboratories® Rabbit anti-MERIT40 IHC Antibody, Affinity Purified - 100 µl (50+ slides)
Catalog #
MERIT40
Human
IHC
Rabbit
Polyclonal
Whole IgG
Between 175 and 225
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Mouse,
Horse,
Dog,
Pig,
Bovine,
Monkey,
Rat
Human
2 - 8 °C
1 year from date of receipt
MERIT40 (mediator of RAP80 interactions and targeting subunit of 40 kDa) is a component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites and leads to targeting of the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. MERIT40 probably also plays a role as a component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q9NWV8].
Alternate Names
BRCA1-A complex subunit MERIT40; BRISC and BRCA1-A complex member 1; C19orf62; HSPC142; mediator of Rap80 interactions and targeting 40 kDa; mediator of RAP80 interactions and targeting subunit of 40 kDa; MERIT40; NBA1; new component of the BRCA1-A complex; new component of the BRCAA1 A complex
Applications
