Bethyl Laboratories
Rabbit anti-MKL1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00637
TargetMKL1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
MKL1 (megakaryoblastic leukemia 1 protein) was identified as part of a t(1;22) translocation with RBM15 associated with acute megakaryoblastic leukemia. It is a transcriptional coactivator of serum response factor (SRF) that promotes muscle differentiation and also plays a role in promoting maturation of megakaryocytes.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 700 and 750
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetMKL1
Antigen Species
Human
Gene ID57591
Gene Symbol
MRTFA
Gene Name
myocardin related transcription factor A
Uniprot IDQ969V6
Protein Name
MKL/myocardin-like protein 1
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to MKL1 immobilized on solid support.
The epitope recognized by IHC-00637 maps to a region between residue 700 and 750 of human megakaryoblastic leukemia (translocation) 1 using the numbering given in entry NP_065882.1 (GeneID 57591).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00637Open
Product DatasheetPDF · IHC-00637 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00637 · Lot 1 (current lot)Open
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