Bethyl Laboratories
Rabbit anti-MLLT1 Antibody Affinity Purified
Primary
Catalog #A302-267A
TargetMLLT1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
MLLT1, also known as ENL (eleven nineteen leukemia protein), was originally identified as a gene involved in a recurrent translocation (11;19) with the mixed-lineage leukemia (MLL) gene. The MLL-ENL fusion protein has been found to associate with SWI/SNF complexes and promote transcription from the HoxA7 promoter. Additionally, from studies to identify proteins that associate with MLLT1, MLLT1 is suggested to play a role in histone modification and transcriptional elongation.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 150 and 200
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetMLLT1
Antigen Species
Human
Gene ID4298
Gene Symbol
MLLT1
Gene Name
MLLT1, super elongation complex subunit
Uniprot IDQ03111
Protein Name
Protein ENL
Alternate Names
CTC-503J8.6 • ENL • ENL/MLL fusion • LTG19 • MLL/ENL fusion protein • MLLT1/MLL fusion • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog) • translocated to, 1 • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) • translocated to, 1 • myeloid/lymphoid or mixed-lineage leukemia • translocated to, 1 • protein ENL • YEATS domain-containing protein 1 • YEATS1
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to MLLT1 immobilized on solid support.
The epitope recognized by A302-267A maps to a region between residue 150 and 200 of human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 using the numbering given in entry NP_005925.2 (GeneID 4298).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A302-267A · Lot 1 (current lot)Open
Product DatasheetPDF · A302-267A · Lot 1 (current lot)Open
Safety Data SheetPDF · A302-267AOpen
Citations / Publications
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