Bethyl Laboratories
Rabbit anti-MLLT1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00648
TargetMLLT1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
MLLT1, also known as ENL (eleven nineteen leukemia protein), was originally identified as a gene involved in a recurrent translocation (11;19) with the mixed-lineage leukemia (MLL) gene. The MLL-ENL fusion protein has been found to associate with SWI/SNF complexes and promote transcription from the HoxA7 promoter. Additionally, from studies to identify proteins that associate with MLLT1, MLLT1 is suggested to play a role in histone modification and transcriptional elongation.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 325 and 375
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetMLLT1
Antigen Species
Human
Gene ID4298
Gene Symbol
MLLT1
Gene Name
MLLT1, super elongation complex subunit
Uniprot IDQ03111
Protein Name
Protein ENL
Alternate Names
CTC-503J8.6 • ENL • ENL/MLL fusion • LTG19 • MLL/ENL fusion protein • MLLT1/MLL fusion • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog) • translocated to, 1 • myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila) • translocated to, 1 • myeloid/lymphoid or mixed-lineage leukemia • translocated to, 1 • protein ENL • YEATS domain-containing protein 1 • YEATS1
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to MLLT1 immobilized on solid support.
The epitope recognized by IHC-00648 maps to a region between residue 325 and 375 of human myeloid/lymphoid or mixed-lineage leukemia (trithorax homolog, Drosophila); translocated to, 1 using the numbering given in entry NP_005925.2 (GeneID 4298).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00648Open
Product DatasheetPDF · IHC-00648 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00648 · Lot 1 (current lot)Open
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