Bethyl Laboratories
Rabbit anti-MST1,2/STK3,4 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00432
TargetMST1-2/STK3-4
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
MST2/STK3 is a member of the sterile 20 (Ste20)-like kinase family that acts upstream of mitogen-activated protein kinase (MAPK) pathways and regulates c-Jun N-terminal kinase (JNK), p38 and extracellular signal-regulated kinase (ERK). Ste20-like kinases are involved in a variety of cellular processes which include gene transcription, stress responses, cytoskeletal organization and apoptosis. In response to apoptotic signals, MST2/STK3 is cleaved by caspase-3 and mediates apoptosis.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 441 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetMST1-2/STK3-4
Antigen Species
Human
Gene ID6788
Gene Symbol
STK3
Gene Name
serine/threonine kinase 3
Uniprot IDQ13188
Protein Name
Serine/threonine-protein kinase 3
Alternate Names
epididymis secretory sperm binding protein • KB-1458E12.1 • KRS1 • mammalian STE20-like protein kinase 2 • MST2 • MST-2 • serine/threonine kinase 3 (STE20 homolog, yeast) • serine/threonine kinase 3 (Ste20, yeast homolog) • serine/threonine-protein kinase 3 • serine/threonine-protein kinase Krs-1 • STE20-like kinase MST2
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to MST1 and MST2 immobilized on solid support.
The epitope recognized by IHC-00432 maps to the C-terminus between residues 450-491 of human Mammalian Sterile 20-like 2 (Serine/Threonine Kinase 3) using the numbering given in Swiss Prot entry Q13188 (GeneID 6788). The epitope is highly conserved with MST1(STK4).
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00432Open
Product DatasheetPDF · IHC-00432 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00432 · Lot 1 (current lot)Open
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