Bethyl Laboratories
Rabbit anti-OSR1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00552
TargetOSR1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
Oxidative stress responsive 1 (OSR1) is a STE20-related kinase involved in ion transport and fluid and ion homeostasis. OSR1 interacts with SPAK (STE20/SPS1-reated proline/alanine-rich kinase) and together are activated by the upstream kinase WNK1 [with no K (lysine) protein kinase-1]. Activation of OSR1 and SPAK by WNK1 results in the phosphorylation and activation of NKCC1 (Na+-K+-2Cl- co-transporter 1) for the control of cell volume and blood pressure.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 375 and 425
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetOSR1
Antigen Species
Human
Gene ID9943
Gene Symbol
OXSR1
Gene Name
oxidative stress responsive 1
Uniprot IDO95747
Protein Name
Serine/threonine-protein kinase OSR1
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to OSR1 immobilized on solid support.
The epitope recognized by IHC-00552 maps to a region between residue 375 and 425 of human oxidative-stress responsive 1 using the numbering given in entry NP_005100.1 (GeneID 9943).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00552Open
Product DatasheetPDF · IHC-00552 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00552 · Lot 1 (current lot)Open
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