Rabbit anti-p150glued Antibody
Catalog #
p150glued
Human
,Mouse
IP
,WB
Rabbit
Polyclonal
Whole IgG
between 1228 and 1278
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Human
2 - 8 °C
1 year from date of receipt
p150glued is the largest subunit of dynactin, a macromolecular complex consisting of 10 subunits ranging in size from 22 to 150 kD. Dynactin binds to both microtubules and cytoplasmic dynein. Dynactin is involved in a diverse array of cellular functions, including ER-to-Golgi transport, the centripetal movement of lysosomes and endosomes, spindle formation, chromosome movement, nuclear positioning, and axonogenesis. The p150glued subunit interacts with dynein intermediate chain by its domains directly binding to dynein and binds to microtubules via a highly conserved glycine-rich cytoskeleton-associated protein (CAP-Gly) domain in its N-terminus [taken from NCBI Entrez Gene (Gene ID: 1639)].
Alternate Names
150 kDa dynein-associated polypeptide; DAP-150; DP-150; dynactin 1 (p150, glued homolog, Drosophila); dynactin subunit 1; P135; p150-glued
Applications