Bethyl Laboratories
Rabbit anti-p300 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00028
Targetp300
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
By sequence similarity p300 is related to CBP (CREB-binding protein) and functions as a histone acetyltransferase that can regulate transcription by influencing chromatin organization. P300 has been demonstrated to bind to phosphorylated CREB to mediate cAMP-gene regulation. P300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha).
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 950 and 1000
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
Targetp300
Antigen Species
Human
Gene ID2033
Gene Symbol
EP300
Gene Name
E1A binding protein p300
Uniprot IDQ09472
Protein Name
Histone acetyltransferase p300
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to p300 immobilized on solid support.
The epitope recognized by IHC-00028 maps to a region between residue 950 and 1000 of human 1A-associated protein p300 using the numbering given in entry NP_001420.2 (GeneID 2033).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00028Open
Product DatasheetPDF · IHC-00028 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00028 · Lot 1 (current lot)Open
Citations / Publications
Services
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