Rabbit anti-p53 IHC Antibody Affinity Purified

Product Details
Specifications
The epitope recognized by IHC-00010 maps to a region between residue 50 and 100 of human tumor protein p53 using the numbering given in entry NP 000537.2 (GeneID 7157). Antibody was affinity purified using an epitope specific to p53 immobilized on solid support.
The epitope recognized by IHC-00010-T maps to a region between residue 50 and 100 of human tumor protein p53 using the numbering given in entry NP 000537.2 (GeneID 7157).
Additional Product Information
p53 is a tumor suppressor protein that is mutated or inactivated in over 50% of human cancers. Loss of function defects in p53 are the cause of the autosomal dominant familial cancer syndrome, Li-Fraumeni syndrome (LFS) that is characterized by the development of a diverse set of malignancies at very early ages. At the cellular level p53 is involved in the negative regulation of cell the cycle via its transactivational control of genes required for cell cycle progression. Depending on the physiological circumstance, p53 can promote growth arrest or apoptosis.
Alternate Names
antigen NY-CO-13; BCC7; cellular tumor antigen p53; LFS1; mutant tumor protein 53; P53; p53 tumor suppressor; phosphoprotein p53; transformation-related protein 53; TRP53; tumor protein 53; Tumor suppressor p53; tumor supressor p53
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.