Bethyl Laboratories
Rabbit anti-p66beta/GATAD2B IHC Antibody Affinity Purified
Primary
Catalog #IHC-00377
Targetp66beta/GATAD2B
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
P66beta/GATAD2B interacts with MBD2 (methyl-CpG-binding domain 2) and MBD3 (methyl-CpG-binding domain 3) and participates in transcriptional repression in association with the MBD2/NuRD and MBD3/NuRD histone deacetylase complexes. P66beta/GATAD2B is SUMOylated in vivo and its repressive activity has been shown to be enhanced by SUMOylation.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 50 and 100
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
Targetp66beta/GATAD2B
Antigen Species
Human
Gene ID57459
Gene Symbol
GATAD2B
Gene Name
GATA zinc finger domain containing 2B
Uniprot IDQ8WXI9
Protein Name
Transcriptional repressor p66-beta
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to p66beta/GATAD2B immobilized on solid support.
The epitope recognized by IHC-00377 maps to a region between residue 50 and 100 of human transcription repressor p66 beta component of the MeCP1 complex (GATA zinc finger domain containing 2B ) using the numbering given in entry NP_065750.1 (GeneID 57459).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00377Open
Product DatasheetPDF · IHC-00377 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00377 · Lot 1 (current lot)Open
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