Rabbit anti-PARP1 Recombinant Monoclonal Antibody [BLR182J]
Catalog #
PARP1
Human
,Mouse
Flow Cyt
,ICC
,IHC
,WB
Rabbit
Recombinant Monoclonal
BLR182J
Whole IgG
Between 775 and 825
IgG
Unconjugated
Purified
Product Details
Mouse,
Human
Human
Human
2 - 8 °C
1 year from date of receipt
Borate Buffered Saline (BBS) pH 8.2 with 0.1% BSA and 0.09% Sodium Azide
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Borate Buffered Saline (BBS) pH 8.2 with 0.09% Sodium Azide, BSA-Free
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Recombinant antibody was purified from cell culture supernatant.
Immunogen was a peptide representing a region between residue 750 and 800 of human Poly [ADP-ribose] polymerase 1 (PARP1) using the numbering given in entry NP_001609.2 (Gene ID 142).
Recombinant antibody was purified from cell culture supernatant.
Immunogen was a peptide representing a region between residue 750 and 800 of human Poly [ADP-ribose] polymerase 1 (PARP1) using the numbering given in entry NP_001609.2 (Gene ID 142).
USA
PARP1 (Poly-ADP-ribose polymerase 1) is a member of PARP family of enzymes that transfer the ADP-D-ribosyl group of NAD(+) to an acceptor carboxyl group on proteins. PARP1 catalyzes the poly-ADP-ribosylation of histone and non-histone proteins in response to DNA damage. The over-activation of PARP-1 in response to DNA damage has been shown to promote cell and tissue injury. This observation has initiated research into the therapeutic potential of PARP1 inhibitors in the treatment of cancer, cardiovascular disease, and brain injury.
Alternate Names
ADP-ribosyltransferase (NAD+; poly (ADP-ribose) polymerase); ADP-ribosyltransferase diphtheria toxin-like 1; ADP-ribosyltransferase NAD(+); ADPRT; ADPRT 1; ADPRT1; ARTD1; NAD(+) ADP-ribosyltransferase 1; pADPRT-1; PARP; PARP-1; poly (ADP-ribose) polymerase family, member 1; poly ADP-ribose polymerase 1; poly(ADP-ribose) synthetase; poly(ADP-ribosyl)transferase; polyADP-ribose synthase 1; PPOL
Applications