Rabbit anti-Pc2 IHC Antibody
Catalog #
Pc2
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 150 and 200
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Guinea_pig,
Dog,
Pig,
Rabbit,
Bovine,
Monkey
Human
2 - 8 °C
1 year from date of receipt
Pc2 (polycomb 2 homolog) is also known as CBX4. Pc2 is an E3 SUMO-protein ligase which facilitates SUMO1 conjugation by UBE2I. It is a component of the Polycomb group (PcG) multiprotein complex, PRC1 (polycomb repressive complex), a complex required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. The PcG-PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/O00257].
Alternate Names
chromobox homolog 4 (Pc class homolog, Drosophila); chromobox protein homolog 4; chromobox-like protein 4; E3 SUMO-protein ligase CBX4; hPc2; NBP16; NS5ATP1-binding protein 16; Pc class 2 homolog; PC2; polycomb 2 homolog
Applications
