Bethyl Laboratories
Rabbit anti-PGC-1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00029
TargetPGC-1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
PGC-1 (PPARgamma coactivator 1) is a nuclear receptor co-activator involved in energy metabolism. PGC-1 was identified as a factor that interacted with the nuclear receptor, PPARgamma. PGC-1 functions as a docking platform for complexes involved in transcriptional regulation such as histone acetyltransferase (HAT) complexes and the TRAP/DRIP (Mediator) complex.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 250 and 300
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetPGC-1
Antigen Species
Human
Gene ID10891
Gene Symbol
PPARGC1A
Gene Name
PPARG coactivator 1 alpha
Uniprot IDQ9UBK2
Protein Name
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha
Alternate Names
LEM6 • Ligand effect modulator 6 • ligand effect modulator-6 • L-PGC-1alpha • peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-3ext • peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B4-8a • peroxisome proliferator-activated receptor gamma coactivator 1 alpha transcript variant B5-NT • peroxisome proliferator-activated receptor gamma coactivator 1-alpha • PGC1 • PGC-1(alpha) • PGC1A • PGC-1alpha • PGC-1-alpha • PGC-1v • PPAR gamma coactivator variant form • PPARgamma coactivator 1alpha • PPAR-gamma coactivator 1-alpha • PPARGC1 • PPARGC-1-alpha
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to PGC-1 immobilized on solid support.
The epitope recognized by IHC-00029 maps to a region between residue 250 and 300 of human peroxisome proliferative activated receptor, gamma, coactivator 1, alpha using the numbering given in SwissProt entry Q9UBK2 (GeneID 10891).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00029Open
Product DatasheetPDF · IHC-00029 · Lot 2 (current lot)Open
Product DatasheetPDF · IHC-00029 · Lot 2 (current lot)Open
Citations / Publications
Services
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