Bethyl Laboratories
Rabbit anti-Phospho XRCC1 (S485/T488) IHC Antibody Affinity Purified
Primary
Catalog #IHC-00117
TargetXRCC1 Phospho (S485/T488)
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
X-ray repair cross-complementing protein 1 (XRCC1) has been identified as a gene that partially rescues a DNA repair defect and therefore plays a role in efficient repair of single-stranded breaks in DNA damage caused by ionizing radiation. XRCC1 interacts with human polynucleotide kinase, DNA polymerase-beta, and DNA ligase III in a multiprotein complex to execute the function of DNA repair.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Surrounding serine 485 and threonine 488
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
50 µg/ml
Target Identity
Antigen Species
Human
Gene ID7515
Gene Symbol
XRCC1
Gene Name
X-ray repair cross complementing 1
Uniprot IDP18887
Protein Name
DNA repair protein XRCC1
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to Phospho XRCC1 (S485/T488) immobilized on solid support.
The epitope recognized by IHC-00117 maps to a region surrounding residues Ser 485 and Thr 488 of human X-ray Repair Complementing protein 1 using the numbering given in SwissProt entry P18887 (GeneID 7515).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00117Open
Product DatasheetPDF · IHC-00117 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00117 · Lot 1 (current lot)Open
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