Rabbit anti-PRCC IHC Antibody Affinity Purified
Catalog #
PRCC
Human
,Mouse
IHC
Rabbit
Polyclonal
Whole IgG
Between 125 and 175
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Mouse,
Human
Monkey
Human
2 - 8 °C
1 year from date of receipt
In a subset of papillary renal cell carcinomas, a t(X;1)(p11;q21) chromosome translocation has been repeatedly reported and is thought to be the cause of the cancer. As a result of the translocation, the transcription factor TFE3 on the X chromosome becomes fused to the PRCC (papillary renal cell carcinoma translocation-associated) gene on chromosome 1. The fused gene results in the fusion of N-terminal proline-rich region of the protein encoded by this gene to the entire TFE3 protein. This protein has been shown to interact with the mitotic checkpoint protein MAD2B, which suggests that the dominant-negative effect of the fusion protein with TFE3 may lead to a mitotic checkpoint defect [taken from NCBI GeneID:5546].
Alternate Names
papillary renal cell carcinoma (translocation-associated); papillary renal cell carcinoma translocation-associated gene protein; PRCC, proline rich mitotic checkpoint control factor; proline-rich protein PRCC; RCCP1; TPRC
Applications
