Bethyl Laboratories
Rabbit anti-REST IHC Antibody Affinity Purified
Primary
Catalog #IHC-00141
TargetREST
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
RE1-Silencing Transcription Factor (REST) is a transcriptional repressor that silences neuronal gene expression in non-neuronal cells by binding to the neuron-restrictive silencer element (NRSE). REST is a Kruppel-type zinc finger transcription factor that mediates repression through its interaction with the mSin3 and CoREST corepressors and the HDAC1 and HDAC2 histone deacetylases.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1047 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetREST
Antigen Species
Human
Gene ID5978
Gene Symbol
REST
Gene Name
RE1 silencing transcription factor
Uniprot IDQ13127
Protein Name
RE1-silencing transcription factor
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to REST immobilized on solid support.
The epitope recognized by IHC-00141 maps to a region between residues 1050 and the C-terminus (residue 1097) of human RE1-silencing transcription factor using the numbering given in entry NP_005603.2 (GeneID 5978).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00141Open
Product DatasheetPDF · IHC-00141 · Lot 2 (current lot)Open
Product DatasheetPDF · IHC-00141 · Lot 2 (current lot)Open
Citations / Publications
Services
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