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Primary Antibodies  

Rabbit anti-SEMA4D Antibody

Bethyl Laboratories®
Bethyl Laboratories®

Catalog #

Validated
Target:

SEMA4D

Reactivity:

Human

Applications:

IP

,

WB

Host:

Rabbit

Clonality:

Polyclonal

Format:

Whole IgG

Immunogen:

Between 812 and 862

Isotype:

IgG

Conjugate:

Unconjugated

Purity:

Antigen Affinity Purified

100 µl (1000 µg/ml)

10 µl (1000 µg/ml)

Product Details

Specifications
Verified Reactivity

Human

Presumed Reactivity

Mouse

Antigen Species

Human

Concentration
1000 µg/ml
Storage

2 - 8 °C

Shelf Life

1 year from date of receipt

Physical State
Liquid
Buffer

Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide


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Additional Product Information

Sema4D (Semaphorin-4D) is a cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Sema4D promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Sema4D regulates dendrite and axon branching and morphogenesis. It promotes the migration of cerebellar granule cells and of endothelial cells. In the immune system Sema4D induces B-cells to aggregate and improves their viability (in vitro). Sema4D also promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q92854].

10507

SEMA4D

semaphorin 4D

Q92854

Semaphorin-4D

Alternate Names

A8; BB18; C9orf164; CD antigen CD100; CD100; COLL4; coll-4; GR3; M-sema-G; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, (semaphorin) 4D; sema domain, immunoglobulin domain (Ig), transmembrane domain (TM) and short cytoplasmic domain, 4D; SEMAJ; semaphorin-4D

Applications

All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.

Western blots of cell lysates are performed using Goat anti-Rabbit IgG Heavy and Light Chain Antibody (Cat. No. A120-101P).

Western blots of immunoprecipitates are performed using Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.