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Rabbit anti-SENP1 Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
SENP1
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 1 and 50
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (200 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Orangutan
Antigen Species
Human
Stock Concentration
40 µg/ml
200 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to SENP1 immobilized on solid support.

The epitope recognized by A302-927A-T maps to a region between residue 1 and 50 of human SUMO1/Sentrin Specific Peptidase 1 using the numbering given in entry NP_055369.1 (GeneID 29843).

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Gene & Protein Information

SENP1 (sentrin-specific protease) functions as a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugation of SUMO1 from HDAC1 decreases its transcriptional repression activity. SENP1 also deconjugates SUMO1 from HIPK2 [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/ Q9P0U3].

29843

SENP1

SUMO specific peptidase 1

Q9P0U3

Sentrin-specific protease 1

Alternate Names

sentrin/SUMO-specific protease SENP1, sentrin-specific protease 1, SUMO1/sentrin specific peptidase 1, SUMO1/sentrin specific protease 1, SuPr-2

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-8% SDS-PAGE. Western blot of lysates performed using standard western blot reagents and 4-8% SDS-PAGE.

Citations (1)