Bethyl Laboratories
Rabbit anti-SMN1 Antibody Affinity Purified
Primary
Catalog #A301-862A
TargetSMN1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
Survival motor neuron protein (SMN1) has been identified as the gene that is defective in spinal muscular atrophy (SMA), a neurodegenerative autosomal recessive disease characterized by paralysis and muscular atrophy which results from the loss of motor neurons in the spinal cord. There are two closely related SMN genes that do not appear to be functionally redundant. SMN1 represents the telomeric copy while SMN2 represents the centromeric copy. In the cell, SMN1 is part of a large complex of proteins involved in snRNP biogenesis. The functional role of SMN1 is proposed to play a role in messenger and ribosomal RNA transcription and processing.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 50 and 100
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetSMN1
Antigen Species
Human
Gene ID6606
Gene Symbol
SMN1
Gene Name
survival of motor neuron 1, telomeric
Uniprot IDQ16637
Protein Name
Survival motor neuron protein
Alternate Names
BCD541 • component of gems 1 • GEMIN1 • gemin-1 • SMA • SMA@ • SMA1 • SMA2 • SMA3 • SMA4 • SMN • SMNT • survival motor neuron 1 protein • survival motor neuron protein • T-BCD541 • TDRD16A • tudor domain containing 16A
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to SMN1 immobilized on solid support.
The epitope recognized by A301-862A maps to a region between residue 50 and 100 of human survival of motor neuron 1 using the numbering given in entry NP_000335.1 (GeneID 6606).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A301-862A · Lot 1 (current lot)Open
Product DatasheetPDF · A301-862A · Lot 1 (current lot)Open
Safety Data SheetPDF · A301-862AOpen
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