Rabbit anti-SNTA1 Antibody
Catalog #
SNTA1
Human
WB
Rabbit
Polyclonal
Whole IgG
Between 50 and 100
IgG
Unconjugated
Antigen Affinity Purified
Product Details
Human
Human
2 - 8 °C
1 year from date of receipt
Syntrophins are cytoplasmic peripheral membrane scaffold proteins that are components of the dystrophin-associated protein complex. Syntrophin-1 (SNTA1) is a member of the syntrophin gene family and encodes the most common syntrophin isoform found in cardiac tissues. The N-terminal PDZ domain of this syntrophin protein interacts with the C-terminus of the pore-forming alpha subunit (SCN5A) of the cardiac sodium channel Nav1.5. This protein also associates cardiac sodium channels with the nitric oxide synthase-PMCA4b (plasma membrane Ca-ATPase subtype 4b) complex in cardiomyocytes. The SNTA1 gene is a susceptibility locus for Long-QT syndrome (LQT) - an inherited disorder associated with sudden cardiac death from arrhythmia - and sudden infant death syndrome (SIDS). This protein also associates with dystrophin and dystrophin-related proteins at the neuromuscular junction and alters intracellular calcium ion levels in muscle tissue [taken from NCBI Entrez Gene (Gene ID: 6640)].
Alternate Names
59 kDa dystrophin-associated protein A1 acidic component 1; acidic alpha 1 syntrophin; alpha-1-syntrophin; dJ1187J4.5; dystrophin-associated protein A1, 59kDa, acidic component; LQT12; pro-TGF-alpha cytoplasmic domain-interacting protein 1; SNT1; syntrophin-1; TACIP1
Applications
