Bethyl Laboratories
Rabbit anti-SRPK1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00685
TargetSRPK1
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
Serine/arginine rich protein-specific kinase 1 (SRPK1) plays a central role in the regulatory network for splicing by controlling the intranuclear distribution of splicing factors in interphase cells and the re-organization of nuclear speckles during mitosis. During metaphase, SRPK1 hyperphosphorylates RS domain-containing proteins such as SFRS1 and SFRS2 on serine residues. SRPK1 also appears to mediate HBV core protein phosphorylation which is a prerequisite for pregenomic RNA encapsidation into viral capsids [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/Q96SB4].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 275 and 325
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetSRPK1
Antigen Species
Human
Gene ID6732
Gene Symbol
SRPK1
Gene Name
SRSF protein kinase 1
Uniprot IDQ96SB4
Protein Name
SRSF protein kinase 1
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to SRPK1 immobilized on solid support.
The epitope recognized by IHC-00685 maps to a region between residue 275 and 325 of human SFRS protein kinase 1 using the numbering given in entry NP_003128.3 (GeneID 6732).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00685Open
Product DatasheetPDF · IHC-00685 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00685 · Lot 1 (current lot)Open
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