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Rabbit anti-STAT2 Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
STAT2
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 725 and 775
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (200 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Antigen Species
Human
Stock Concentration
40 µg/ml
200 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to STAT2 immobilized on solid support.

The epitope recognized by A303-511A-T maps to a region between residue 725 and 775 of human Signal Transducer and Activator of Transcription 2 using the numbering given in entry NP_005410.1 (GeneID 6773).

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Gene & Protein Information

Signal transducer and activator of transcription 2 (STAT2) is a signal transducer and activator of transcription that mediates signaling by type I IFNs (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with ISGF3G/IRF-9 to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state [taken from the Universal Protein Resource (UniProt) www.uniprot.org/uniprot/P52630].

6773

STAT2

signal transducer and activator of transcription 2

P52630

Signal transducer and activator of transcription 2

Alternate Names

IMD44, interferon alpha induced transcriptional activator, ISGF-3, P113, signal transducer and activator of transcription 2, signal transducer and activator of transcription 2, 113kDa, STAT113

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-8% SDS-PAGE. Western blot of lysates performed using standard western blot reagents and 4-8% SDS-PAGE.