Bethyl Laboratories
Rabbit anti-TIF1 Alpha/TRIM24 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00144
TargetTIF1 Alpha/TRIM24
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
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Product Description
TIF1 Alpha/TRIM24 is a member of a family of proteins that control transcription and chromatin remodeling through their interaction with transcription factors. The family of TIF1s (transcriptional intermediary factor 1) includes TIF1-alpha, TIF1-beta, and TIF1-gamma. TIF1-alpha plays an important role in development and mediates transcriptional control by interacting with the AF2 region of nuclear receptors such as estrogen, retinoic acid, and vitamin D3 receptors. TIF1-alpha has been shown to be a repressor of transcription. This transcriptional repression involves histone deacetylation and interaction with members of the heterochromatin protein 1 family.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 700 and 750
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetTIF1 Alpha/TRIM24
Antigen Species
Human
Gene ID8805
Gene Symbol
TRIM24
Gene Name
tripartite motif containing 24
Uniprot IDO15164
Protein Name
Transcription intermediary factor 1-alpha
Alternate Names
E3 ubiquitin-protein ligase TRIM24 • hTIF1 • PTC6 • RING finger protein 82 • RING-type E3 ubiquitin transferase TIF1-alpha • RNF82 • TF1A • TIF1 • TIF1A • TIF1ALPHA • TIF1-alpha • transcription intermediary factor 1-alpha • transcriptional intermediary factor 1 • Tripartite motif-containing protein 24
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to TIF1 Alpha/TRIM24 immobilized on solid support.
The epitope recognized by IHC-00144 maps to a region between residues 700 and 750 of human Transcriptional Intermediary Factor 1 Alpha (Tripartite Motif-Containing 24 ) using the numbering given in entry NP_056989.2 (GeneID 8805).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00144Open
Product DatasheetPDF · IHC-00144 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00144 · Lot 1 (current lot)Open
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