Bethyl Laboratories
Rabbit anti-TORC1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00452
TargetTORC1
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
Image 1 of 2
local_shipping
Order within 9 hours and 44 minutes for shipment by today
Product Description
TORC1 (transducer of regulated CREB activity 1) is part of a family of CREB (cAMP response element-binding protein) coactivators that also includes TORC2 and TORC3. These proteins function to activate CREB-dependent transcription in response to cAMP and calcium signaling pathways. The TORC family of proteins has been shown to regulate transcription of PGC-1 alpha, a regulator of mitochondrial genes.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 584 and C-terminus
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetTORC1
Antigen Species
Human
Gene ID23373
Gene Symbol
CRTC1
Gene Name
CREB regulated transcription coactivator 1
Uniprot IDQ6UUV9
Protein Name
CREB-regulated transcription coactivator 1
Alternate Names
CREB-regulated transcription coactivator 1 • Mam-2 • MAML2 • Mastermind-like protein 2 • MECT1 • mucoepidermoid carcinoma translocated protein 1 • TORC1 • TORC-1 • Transducer of CREB protein 1 • transducer of regulated cAMP response element-binding protein (CREB) 1 • Transducer of regulated cAMP response element-binding protein 1 • WAMTP1
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to TORC1 immobilized on solid support.
The epitope recognized by IHC-00452 maps to a region between residue 600 and the C-terminus (residue 634) of human Transducer of Regulated cAMP Response element-binding protein 1 (CREB Regulated Transcription Coactivator 1) using the numbering given in entry NP_056136.1 (GeneID 23373 ).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00452Open
Product DatasheetPDF · IHC-00452 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00452 · Lot 1 (current lot)Open
Services
Antibody Conjugation
Antibody and conjugate formats developed together, built to your specification.
Request CustomizationCustom Monoclonal Antibody Discovery Services
Full custom monoclonal development, from immunization through validation.
Explore Monoclonal DevelopmentVHH Discovery
Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
Explore VHH DiscoveryResources
1