Bethyl Laboratories
Rabbit anti-UVRAG IHC Antibody Affinity Purified
Primary
Catalog #IHC-00590
TargetUVRAG
HostRabbit
ClonalityPolyclonal
ReactivityMouse, Human
ApplicationIHC
Image 1 of 2
local_shipping
Order within 4 hours and 43 minutes for shipment by Tuesday, November 10
Product Description
UV radiation resistance associated gene (UVRAG) was first identified as a gene that could complement UV sensitivity in xeroderma pigmentosum cells. UVRAG may have tumor suppressor activity as mutations in the UVRAG gene have been associated with various human colon cancer cells and tissues. UVRAG has been shown to interact with Beclin 1 (Bcl-2-interacting protein), a protein that forms a complex with class III PI-3-kinase (PI3KC3) and is involved in autophagy. In this complex, UVRAG is proposed to function as a positive regulator of autophagy and a negative regulator of the growth of tumor cells.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 649 and C-terminus
Isotype
IgG
Reactivity
Mouse, Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetUVRAG
Antigen Species
Human
Gene ID7405
Gene Symbol
UVRAG
Gene Name
UV radiation resistance associated
Uniprot IDQ9P2Y5
Protein Name
UV radiation resistance-associated gene protein
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to UVRAG immobilized on solid support.
The epitope recognized by IHC-00590 maps to a region between residue 649 and 699 of human UV radiation resistance associated gene using the numbering given in entry NP_003360.2 (GeneID 7405).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer or tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00590Open
Product DatasheetPDF · IHC-00590 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00590 · Lot 1 (current lot)Open
Services
Antibody Conjugation
Antibody and conjugate formats developed together, built to your specification.
Request CustomizationCustom Monoclonal Antibody Discovery Services
Full custom monoclonal development, from immunization through validation.
Explore Monoclonal DevelopmentVHH Discovery
Single-domain antibodies for structurally difficult targets a conventional monoclonal can't reach.
Explore VHH DiscoveryResources
1