Bethyl Laboratories
Rabbit anti-WRN IHC Antibody Affinity Purified
Primary
Catalog #IHC-00407
TargetWRN
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
The protein product of the Werner’s syndrome (WRN) gene is the Werner syndrome ATP-dependent helicase. WRN is part of the ReqQ family of helicases that unwind DNA in preparation for replication, transcription, and repair. WRN appears to play a versatile role in cellular processes including DNA replication, transcription and the maintenance of genomic integrity.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1382 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetWRN
Antigen Species
Human
Gene ID7486
Gene Symbol
WRN
Gene Name
Werner syndrome RecQ like helicase
Uniprot IDQ14191
Protein Name
Werner syndrome ATP-dependent helicase
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to WRN immobilized on solid support.
The epitope recognized by IHC-00407 maps to a region between residues 1400 and the C-terminus (residue 1432) of human Werner Syndrome Helicase using the numbering given in SwissProt entry Q14191 (GeneID 7486).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00407Open
Product DatasheetPDF · IHC-00407 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00407 · Lot 1 (current lot)Open
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