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Rabbit anti-WRNIP1 Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
WRNIP1
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 400 and 450
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (1000 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Rat, Mouse
Antigen Species
Human
Stock Concentration
400 µg/ml
1000 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to WRNIP1 immobilized on solid support.

The epitope recognized by A301-389A-T maps to a region between residue 400 and 450 of human Werner helicase interacting protein 1 using the numbering given in entry NP_064520.2 (GeneID 56897).

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Gene & Protein Information

WRNIP1 (Werner helicase interacting protein 1) was identified as a protein that interacts with the N-terminal region of Werner protein (WRN). WRN is a RecQ DNA helicase important to DNA repair and is the causative gene of Werner syndrome (WS), an autosomal recessive disease characterized by premature aging. WRNIP1 has been shown to interact with DNA polymerase delta (pol delta) and play a role in pol delta-mediated DNA synthesis. Additionally, WRNIP1 has been shown to interact with polyubiquitin chains indicating a link between ubiquitination and the DNA repair pathway.

56897

WRNIP1

Werner helicase interacting protein 1

Q96S55

ATPase WRNIP1

Alternate Names

ATPase WRNIP1, bA420G6.2, putative helicase RUVBL, Werner helicase-interacting protein 1, WHIP

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-8% SDS-PAGE. Western blot of lysates performed using standard western blot reagents and 4-8% SDS-PAGE.