Bethyl Laboratories
Rabbit anti-XLF IHC Antibody Affinity Purified
Primary
Catalog #IHC-00185
TargetXLF
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
XRCC4-like factor (XLF) functions in DNA nonhomologous end joining (NHEJ) in double-strand break repair and immune system V(D)J recombination. Mutations of XLF in humans have been documented to result in immunodeficiency, growth retardation, and microcephaly. The yeast of homolog of XLF is Nej1. XLF has been shown to interact with the XRCC4 x DNA-ligase IV complex and is implicated in the DNA religation step of the NHEJ pathway.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 225 and 275
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetXLF
Antigen Species
Human
Gene ID79840
Gene Symbol
NHEJ1
Gene Name
non-homologous end joining factor 1
Uniprot IDQ9H9Q4
Protein Name
Non-homologous end-joining factor 1
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to XLF immobilized on solid support.
The epitope recognized by IHC-00185 maps to a region between residues 200 and 250 of human XRCC4-Like Factor using the numbering given in entry NP_079058.1 (GeneID 79840).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00185Open
Product DatasheetPDF · IHC-00185 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00185 · Lot 1 (current lot)Open
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