Bethyl Laboratories
Rabbit anti-XPC Antibody Affinity Purified
Primary
Catalog #A301-121A
TargetXPC
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIP
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Product Description
Defects in XPC are a cause of xeroderma pigmentosum complementation group C, a rare autosomal recessive diseased characterized by hypersensitivity to sunlight and an elevated risk of skin cancer on sun-exposed areas. XPC is involved in nucleotide excision repair and performs its function as part of a heterodimeric complex with HHR23B. XPC has been found to play a role in the early stages of repair that involve incising damaged DNA.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 850 and 900
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
1000 µg/ml
Target Identity
TargetXPC
Antigen Species
Human
Gene ID7508
Gene Symbol
XPC
Gene Name
XPC complex subunit, DNA damage recognition and repair factor
Uniprot IDQ01831
Protein Name
DNA repair protein complementing XP-C cells
Product Information
Applications
IP
Buffer
Tris-citrate/phosphate buffer, pH 7 to 8 containing 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to XPC immobilized on solid support.
The epitope recognized by A301-121A maps to a region between residue 825 and 875 of human xeroderma pigmentosum, complementation group C using the numbering given in entry NP_004619.2 (GeneID 7508).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
All western blot analysis is performed using 5% Milk-TBST for blocking and as antibody diluent. Primary antibody is incubated overnight.
Western blots of immunoprecipitates are performed using an anti-Rabbit IgG Light Chain HRP-conjugated antibody with 5% Normal Pig Serum (Cat. No. S100-020) added to the blocking buffer.
Immunoprecipitation (IP)6 µg/mg lysate
Documents
Product DatasheetPDF · A301-121A · Lot 1 (current lot)Open
Product DatasheetPDF · A301-121A · Lot 1 (current lot)Open
Safety Data SheetPDF · A301-121AOpen
Citations / Publications
Services
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