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Rabbit anti-ZNF198 Antibody

Bethyl Laboratories®

Bethyl Laboratories® Catalog #

Validated
Target:
ZNF198
Reactivity:
Human
Host:
Rabbit
Clonality:
Polyclonal
Format:
Whole IgG
Immunogen:
between 975 and 1025
IsoType:
IgG
Purity:
Antigen Affinity Purified
100 µl (200 µg/ml)

100 µl (10 blots)

20 µl (2 blots)

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Product Details

Specifications
Verified Reactivity
Human
Presumed Reactivity
Orangutan
Antigen Species
Human
Stock Concentration
100 µg/ml
200 µg/ml
Storage
2 - 8 °C
Shelf Life
1 year from date of receipt
Physical State
Liquid
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
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Prod Procedures
Antibody was affinity purified using an epitope specific to ZNF198 immobilized on solid support.

The epitope recognized by A301-710A-T maps to a region between residue 975 and 1025 of human zinc finger protein 198 using the numbering given in entry NP_003444.1 (GeneID 7750).

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Gene & Protein Information

ZNF198 contains nine MYM-type zinc fingers. The N-terminal half of the ZNF198 gene has been identified as a gene fused to the cytoplasmic domain of the fibroblast growth factor receptor (FGFR1) gene as a result of a t(8;13) (p11;q11-12) chromosomal rearrangement. The t(8;13) chromosomal translocation is associated with myeloproliferative diseases such as stem cell leukemia lymphoma syndrome (SCLL). Studies of the normal function of ZNF198 have revealed that it associates with HHR6 and RAD18 and may be involved in the repair of DNA. ZNF198 has also been found to associate with the BHC110 subunit of a histone-deacetylase containing corepressor complex and may have an additional function in transcriptional repression.

7750

ZMYM2

zinc finger MYM-type containing 2

Q9UBW7

Zinc finger MYM-type protein 2

Alternate Names

FIM, fused in myeloproliferative disorders protein, MYM, RAMP, rearranged in an atypical myeloproliferative disorder, Rearranged in atypical myeloproliferative disorder protein, SCLL, zinc finger MYM-type protein 2, zinc finger protein 198, zinc finger, MYM-type 2, ZNF198

Applications

Western blot of immunoprecipitates performed using Normal Pig Serum (Cat. No. S100-020), Goat anti-Rabbit Light Chain HRP Conjugate (Cat. No. A120-113P) and 4-8% SDS-PAGE. Western blot of lysates performed using standard western blot reagents and 4-8% SDS-PAGE.