Bethyl Laboratories
Rabbit anti-DNA-PKcs IHC Antibody Affinity Purified
Primary
Catalog #IHC-00044
TargetDNA-PKcs
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
DNA-PKcs is the catalytic subunit of a DNA-dependent serine-threonine protein kinase (DNA-PK). DNA-PK is a heterotrimer comprised of DNA-PKcs and the Ku709/Ku86 dimer. DNA-PK is involved in DNA damage repair and V(D)J recombination. DNA-PK phosphorylates Artemis, a protein required for nonhomologous end-joining and is necessary for the loading of Artemis on damaged DNA.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 2100 and 2150
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetDNA-PKcs
Antigen Species
Human
Gene ID5591
Gene Symbol
PRKDC
Gene Name
protein kinase, DNA-activated, catalytic subunit
Uniprot IDP78527
Protein Name
DNA-dependent protein kinase catalytic subunit
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to DNA-PKcs immobilized on solid support.
The epitope recognized by IHC-00044 maps to a region between residue 2100 and 2150 of human DNA-Dependent Protein Kinase, catalytic subunit using the numbering given in entry NP_008835.5 (GeneID 5591).
Applications
Epitope exposure is recommended.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00044Open
Product DatasheetPDF · IHC-00044 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00044 · Lot 1 (current lot)Open
Citations / Publications
Services
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