Bethyl Laboratories
Rabbit anti-ACINUS/ACN1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00215
TargetACINUS/ACN1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
Acinus (Apoptotic Chromatin Condensation Inducer of the Nucleus) has been demonstrated to play a dual role in apoptosis and mRNA splicing. A proteolytic fragment of acinus generated by caspase cleavage appears to mediate chromatin condensation and DNA fragmentation. Acinus is also part of the ASAP (apoptosis and splicing-associated protein) complex that is deposited at exon-exon junctions during RNA splicing. In this complex acinus may be involved in pre-mRNA splicing.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1291 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetACINUS/ACN1
Antigen Species
Human
Gene ID22985
Gene Symbol
ACIN1
Gene Name
apoptotic chromatin condensation inducer 1
Uniprot IDQ9UKV3
Protein Name
Apoptotic chromatin condensation inducer in the nucleus
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to ACINUS/ACN1 immobilized on solid support.
The epitope recognized by IHC-00215 maps to a region between residue 1291 and the C-terminus (residue 1341) of human apoptotic chromatin condensation inducer 1 using the numbering given in entry NP_055792.1 (GeneID 22985).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00215Open
Product DatasheetPDF · IHC-00215 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00215 · Lot 1 (current lot)Open
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