Bethyl Laboratories
Rabbit anti-ATRX IHC Antibody Affinity Purified
Primary
Catalog #IHC-00236
TargetATRX
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
ATRX (alpha-thalassemia mental retardation X-linked) is a chromatin remodeling protein and transacting regulator of globin gene expression that has been linked to several X-linked mental retardation syndromes and hematologic diseases such as myelodysplasia. ATRX possesses an ATPase/helicase domain and is related to the SWI/SNF family of proteins. Mutations in ATRX have been demonstrated to cause changes in DNA methylation patterns and gene expression important to development.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 2442 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetATRX
Antigen Species
Human
Gene ID546
Gene Symbol
ATRX
Gene Name
ATRX, chromatin remodeler
Uniprot IDP46100
Protein Name
Transcriptional regulator ATRX
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to ATRX immobilized on solid support.
The epitope recognized by IHC-00236 maps to a region between residue 2442 and the C-terminus (residue 2492) of human alpha thalassemia/mental retardation syndrome X-linked using the numbering given in entry NP_000480.2 (GeneID 546).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00236Open
Product DatasheetPDF · IHC-00236 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00236 · Lot 1 (current lot)Open
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