Bethyl Laboratories
Rabbit anti-BCCIP IHC Antibody Affinity Purified
Primary
Catalog #IHC-00636
TargetBCCIP
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC, IHC-IF
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Product Description
BCCIP (BRCA2 and CDKN1A interacting protein) was isolated as a BRCA2 and p21 interacting protein. Downregulation of BCCIP results in chromosome instability and incomplete cytokinesis indicating a role in DNA damage. Additionally, BCCIP is critical for BRCA2- and Rad51-dependent homologous recombinational repair.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 264 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetBCCIP
Antigen Species
Human
Gene ID56647
Gene Symbol
BCCIP
Gene Name
BRCA2 and CDKN1A interacting protein
Uniprot IDQ9P287
Protein Name
BRCA2 and CDKN1A-interacting protein
Product Information
Applications
IHC, IHC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to BCCIP immobilized on solid support.
The epitope recognized by IHC-00636 maps to a region between residue 300 and 350 of human BRCA2 and CDKN1A interacting protein using the numbering given in entry NP_510868.1 (GeneID 56647).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Immunohistochemistry-Immunofluoresence (IHC-IF)1:50 - 1:500
Documents
Safety Data SheetPDF · IHC-00636Open
Product DatasheetPDF · IHC-00636 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00636 · Lot 1 (current lot)Open
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