Bethyl Laboratories
Rabbit anti-CSN1 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00113
TargetCSN1
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
CSN1 is one of eight subunits (CSN1 to 8) of the highly conserved COP9 signalsome (CSN) complex originally identified as a regulator of light-mediated development in Arabidopsis. Characterization of CSN from yeast to mammals reveals a function as a modulator of signal transduction pathways involved in a variety of cellular and developmental processes. One of the major functions of the CSN is the regulation of protein degradation via intersection with the ubiquitin-proteasome pathway and regulation of E3-ubiquitin ligases.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 441 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetCSN1
Antigen Species
Human
Gene ID2873
Gene Symbol
GPS1
Gene Name
G protein pathway suppressor 1
Uniprot IDQ13098
Protein Name
COP9 signalosome complex subunit 1
Alternate Names
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to CSN1 immobilized on solid support.
The epitope recognized by IHC-00113 maps to a region between residues 400 and the C-terminus (residue 471) of human G protein Pathway Suppressor 1 using the numbering given in Swiss-Prot entry Q13098 (GeneID 2873).
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00113Open
Product DatasheetPDF · IHC-00113 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00113 · Lot 1 (current lot)Open
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