Bethyl Laboratories
Rabbit anti-Cyclin C IHC Antibody Affinity Purified
Primary
Catalog #IHC-00592
TargetCyclin C
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
Cyclin C is a member of the cyclin family of regulatory proteins that associate with and activate cyclin-dependent kinases (CDKs) to regulate cell cycle progression. Cyclins exhibit periodicity in their expression and activity which is regulated transcriptionally and post-transcriptionally via phosphorylation and ubiquitination. Cyclin C associates with cyclin-dependent kinase 8 (CDK8). It is also a component of the Mediator complex, a coactivator complex that provides a scaffold to link gene-specific transcription factors to RNA polymerase II and the general transcription machinery.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 233 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetCyclin C
Antigen Species
Human
Gene ID892
Gene Symbol
CCNC
Gene Name
cyclin C
Uniprot IDP24863
Protein Name
Cyclin-C
Alternate Names
CycC • cyclin-C • hSRB11 • SRB11 • SRB11 homolog
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to Cyclin C immobilized on solid support.
The epitope recognized by IHC-00592 maps to a region between residue 244 and 294 of human cyclin C using the numbering given in entry NP_005181.2 (GeneID 892).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer or tris-EDTA pH9.0 buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00592Open
Product DatasheetPDF · IHC-00592 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00592 · Lot 1 (current lot)Open
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