Bethyl Laboratories
Rabbit anti-RSK2 IHC Antibody Affinity Purified
Primary
Catalog #IHC-00683
TargetRSK2
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC, IHC-IF
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Product Description
Ribosomal protein S6 kinase alpha-2 (RSK2) is a member of the RSK (ribosomal S6 kinase) family of serine/threonine kinases. RSK2 kinase contains 2 non-identical kinase catalytic domains and phosphorylates various substrates, including members of the mitogen-activated kinase (MAPK) signaling pathway. The activity of this protein has been implicated in controlling cell growth and differentiation. Mutations in this gene have been associated with Coffin-Lowry syndrome [taken from NCBI Entrez Gene (GeneID: 6197)].
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1 and 50
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
250 µg/ml
Target Identity
TargetRSK2
Antigen Species
Human
Gene ID6197
Gene Symbol
RPS6KA3
Gene Name
ribosomal protein S6 kinase A3
Uniprot IDP51812
Protein Name
Ribosomal protein S6 kinase alpha-3
Alternate Names
90 kDa ribosomal protein S6 kinase 3 • CLS • epididymis secretory sperm binding protein • HU-3 • insulin-stimulated protein kinase 1 • ISPK-1 • MAP kinase-activated protein kinase 1b • MAPK-activated protein kinase 1b • MAPKAP kinase 1b • MAPKAPK1B • MAPKAPK-1b • MRX19 • p90-RSK 3 • p90-RSK2 • p90RSK3 • pp90RSK2 • ribosomal protein S6 kinase alpha-3 • ribosomal protein S6 kinase, 90kDa, polypeptide 3 • ribosomal S6 kinase 2 • RSK • RSK2 • RSK-2 • S6K-alpha3 • S6K-alpha-3
Product Information
Applications
IHC, IHC-IF
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to RSK2 immobilized on solid support.
The epitope recognized by IHC-00683 maps to a region between residue 1 and 50 of human ribosomal S6 kinase 2 using the numbering given in entry NP_004577.1 (GeneID 6197).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Immunohistochemistry-Immunofluoresence (IHC-IF)1:50 - 1:500
Documents
Safety Data SheetPDF · IHC-00683Open
Product DatasheetPDF · IHC-00683 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00683 · Lot 1 (current lot)Open
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