Bethyl Laboratories
Rabbit anti-SFRS2IP IHC Antibody Affinity Purified
Primary
Catalog #IHC-00541
TargetSFRS2IP
HostRabbit
ClonalityPolyclonal
ReactivityHuman
ApplicationIHC
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Product Description
SFRS2IP was identified as factor that interacts with SC35, an SR family member critical to mRNA splicing. SFRS2IP contains an arginine-serine-rich (RS) domain and lacks any known RNA-binding motifs. SFRS2IP may have an important role in splicesome assembly since it has been demonstrated to interact with several proteins involved in the early steps of splicesome assembly and the finding that splicesomal complexes A and B are not formed in SFRS2IP depleted extracts.
Specifications
Clonality
Polyclonal
Host
Rabbit
Immunogen
Between 1413 and C-terminus
Isotype
IgG
Reactivity
Human
Format
Whole IgG
Conjugate Type
Unconjugated
Purity
Antigen Affinity Purified
Concentration
100 µg/ml
Target Identity
TargetSFRS2IP
Antigen Species
Human
Gene ID9169
Gene Symbol
SCAF11
Gene Name
SR-related CTD associated factor 11
Uniprot IDQ99590
Protein Name
Protein SCAF11
Alternate Names
CASP11 • CTD-associated SR protein 11 • protein SCAF11 • renal carcinoma antigen NY-REN-40 • SC35-interacting protein 1 • serine/arginine-rich splicing factor 2-interacting protein • SFRS2-interacting protein • SFRS2IP • SIP1 • splicing factor, arginine/serine-rich 2-interacting protein • splicing regulatory protein 129 • SR-related and CTD-associated factor 11 • SRRP129 • SRSF2-interacting protein • SRSF2IP
Product Information
Applications
IHC
Buffer
Tris-buffered Saline containing 0.1% BSA and 0.09% Sodium Azide
Storage Conditions
2 - 8 °C
Physical State
Liquid
Shelf Life
1 year from date of receipt
Country of Origin
USA
Production & Epitope
Antibody was affinity purified using an epitope specific to SFRS2IP immobilized on solid support.
The epitope recognized by IHC-00541 maps to a region between residue 1098 and the C-terminus (residue 1148) of human splicing factor, arginine/serine-rich 2, interacting protein using the numbering given in entry CAA72121.1 (GeneID 9169).
Immunoglobulin concentration was determined using Beer’s Law where 1mg/mL IgG has an A280 of 1.4.
Applications
Epitope exposure is recommended.
Epitope exposure with citrate buffer will enhance staining.
Likely to work with frozen sections.
In some cases, the antibody may be diluted further than indicated.
Immunohistochemistry (IHC)1:100 - 1:500
Documents
Safety Data SheetPDF · IHC-00541Open
Product DatasheetPDF · IHC-00541 · Lot 1 (current lot)Open
Product DatasheetPDF · IHC-00541 · Lot 1 (current lot)Open
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